Mantralayam is the sacred home of the Jeeva Samadhi of the 17th-century Madhva saint, Sri Raghavendra Swamy, a major pilgrimage center for Vaishnava devotees globally. Located on the banks of the Tungabhadra River, it is the most significant spiritual site in the Kurnool District, attracting millions annually for blessings at his holy Brindavanam.